Well below is the list of add-ons I like to use with thunderbird
1) Thunderbird Conversations: This is a must have add-on. This addon provides a conversation view for Thunderbird, including contacts tooltips, attachment thumbnails, quick (inline) reply, integration with other addons, and much more.
2) QuickFolders: Cut through the clutter of the folders sidebar with your favorite folders as tabs. Open folders and sub folders, move mails without scrolling around or searching.
I am using the above two add-ons and enabled vertical layout and hidden the folder pane. Look at the screenshot below
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